CVE-2024-50636Public exploitNetwork attack vector

Code execution via unrestricted PYM script loading

Published Nov 11, 2024 · Updated Nov 19, 2024

Code injection in Schrödinger PyMOL 2.5.0 allows remote attackers to execute Python code through a crafted .PYM file. The Run Script function treats the file as a Python script without validating or restricting its embedded commands. The payload runs only when the crafted file is passed to Run Script, and it executes with the privileges of the account running PyMOL.

CVSS severity9.8
Critical
EPSS probability1.25%
Next 30 days · Sep 16, 2026
Known exploitationUnconfirmed
Based on sourced intelligence
Hinoki checkNot available
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Summary

What happened

Code injection in Schrödinger PyMOL 2.5.0 allows remote attackers to execute Python code through a crafted .PYM file. The Run Script function treats the file as a Python script without validating or restricting its embedded commands. The payload runs only when the crafted file is passed to Run Script, and it executes with the privileges of the account running PyMOL.

The record

CVE
CVE-2024-50636
Published
Nov 11, 2024
Updated
Nov 19, 2024
Vendor
Schrödinger
Product
PyMOL
Classifications
CWE-94, T1059.006
Attack vector
network
Privileges
unauthenticated

Timeline

How it unfolded

  1. Nov 11, 2024CVE publishedPublication date reported by the CVE source.
  2. Nov 19, 2024Record updatedLatest update available in the CVE record.

Exploitability

Present is not the same as exploitable

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Is a vulnerable build present?

Compare these published version ranges with your installed build and any vendor patches.

  1. Affected versionversion=2.5.0

What conditions does exploitation require?

Attack vectornetwork
Required privilegesunauthenticated

What is affected?

Schrödinger · PyMOLversion=2.5.0

Published CVSS scores

9.8CanonicalCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H

CVSS describes severity. EPSS estimates exploitation probability.

Attacks

What attackers are doing with it

Daily unique IPs observed by Shadowserver honeypots for known exploited vulnerabilities (KEVs). Missing observations do not establish an absence of attacks.

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No observations available

Sep 10, 2026Sep 16, 2026
Latest reporting daySep 16, 2026
Latest daily unique IPsUnavailable
Prior 30-day averageUnavailable
SourceShadowserver honeypots (KEV)
Vectornetwork
Privilegesunauthenticated
Known exploitationUnconfirmed
Public exploitPublished

Weakness, pattern, technique

CWE-94Improper Control of Generation of Code ('Code Injection')
T1059.006Command and Scripting Interpreter: Python

Public exploit references

Labels summarize the accepted research assessment. They do not indicate a test against your environment.

Technologies

Your stack

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Your stack

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