CVE-2022-1521Network attack vector

Unauthenticated data interception via missing access controls

Published Jun 24, 2022 · Updated Apr 16, 2025

Improper access control in Illumina Local Run Manager 1.3 through 3.1 allows remote attackers to intercept and modify sensitive data. The default LRM web interface accepts requests without authenticating the requester or authorizing the requested operation. Network access to an affected instrument or off-instrument LRM instance is sufficient to inject, replay, modify, or intercept sensitive data.

CVSS severity9.1
Critical
EPSS probability1.12%
Next 30 days · Sep 16, 2026
Known exploitationUnconfirmed
Based on sourced intelligence
Hinoki checkNot available
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Summary

What happened

Improper access control in Illumina Local Run Manager 1.3 through 3.1 allows remote attackers to intercept and modify sensitive data. The default LRM web interface accepts requests without authenticating the requester or authorizing the requested operation. Network access to an affected instrument or off-instrument LRM instance is sufficient to inject, replay, modify, or intercept sensitive data.

The record

CVE
CVE-2022-1521
Published
Jun 24, 2022
Updated
Apr 16, 2025
Vendor
Illumina
Product
MiSeqDx Instrument
Classifications
CWE-284, CWE-862, CWE-306, T1190
Attack vector
network
Privileges
unauthenticated

Timeline

How it unfolded

  1. Jun 24, 2022CVE publishedPublication date reported by the CVE source.
  2. Apr 16, 2025Record updatedLatest update available in the CVE record.

Exploitability

Present is not the same as exploitable

Compare your product and version with the public record. A matching version still requires validation against your environment.

Is a vulnerable build present?

Compare these published version ranges with your installed build and any vendor patches.

  1. Affected versionversion=LRM Versions 1.3 to 3.1

What conditions does exploitation require?

Attack vectornetwork
Required privilegesunauthenticated

What is affected?

Illumina · MiSeqDx Instrumentversion=LRM Versions 1.3 to 3.1
Illumina · MiniSeq Systemversion=LRM Versions 1.3 to 3.1
Illumina · iSeq 100version=LRM Versions 1.3 to 3.1
Illumina · NextSeq 550Dx Instrumentversion=LRM Versions 1.3 to 3.1
Illumina · NextSeq 550 Systemversion=LRM Versions 1.3 to 3.1
Illumina · MiSeq Systemversion=LRM Versions 1.3 to 3.1
Illumina · NextSeq 500 Systemversion=LRM Versions 1.3 to 3.1

Published CVSS scores

6.4NISTAV:N/AC:L/Au:N/C:P/I:P/A:N
9.1ICS-CERTCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:N

CVSS describes severity. EPSS estimates exploitation probability.

Attacks

What attackers are doing with it

Daily unique IPs observed by Shadowserver honeypots for known exploited vulnerabilities (KEVs). Missing observations do not establish an absence of attacks.

Daily unique IPsNo honeypot observations are available for this CVE in the selected window.

No observations available

Sep 10, 2026Sep 16, 2026
Latest reporting daySep 16, 2026
Latest daily unique IPsUnavailable
Prior 30-day averageUnavailable
SourceShadowserver honeypots (KEV)
Vectornetwork
Privilegesunauthenticated
Known exploitationUnconfirmed
Public exploitUnconfirmed

Weakness, pattern, technique

CWE-284Improper Access Control
CWE-862Missing Authorization
CWE-306Missing Authentication for Critical Function
T1190Exploit Public-Facing Application

Public exploit references

No public exploit references are available in this record.

Labels summarize the accepted research assessment. They do not indicate a test against your environment.

Technologies

Your stack

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Your stack

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