CVE-2022-1518Network attack vector

Remote code execution via path-traversal upload

Published Jun 24, 2022 · Updated Apr 16, 2025

Path traversal in Illumina Local Run Manager 1.3 through 3.1 allows remote attackers to upload files outside the intended directory. The network-accessible IIS web interface permits uploaded content to escape the intended directory, and its configuration allows that content to execute. No authentication or user interaction is required, and successful exploitation grants operating-system-level control over instrument settings, software, and data.

CVSS severity10.0
Critical
EPSS probability1.63%
Next 30 days · Sep 16, 2026
Known exploitationUnconfirmed
Based on sourced intelligence
Hinoki checkNot available
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Summary

What happened

Path traversal in Illumina Local Run Manager 1.3 through 3.1 allows remote attackers to upload files outside the intended directory. The network-accessible IIS web interface permits uploaded content to escape the intended directory, and its configuration allows that content to execute. No authentication or user interaction is required, and successful exploitation grants operating-system-level control over instrument settings, software, and data.

The record

CVE
CVE-2022-1518
Published
Jun 24, 2022
Updated
Apr 16, 2025
Vendor
Illumina
Product
MiSeqDx Instrument
Classifications
CWE-22, T1190
Attack vector
network
Privileges
unauthenticated

Timeline

How it unfolded

  1. Jun 24, 2022CVE publishedPublication date reported by the CVE source.
  2. Apr 16, 2025Record updatedLatest update available in the CVE record.

Exploitability

Present is not the same as exploitable

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Is a vulnerable build present?

Compare these published version ranges with your installed build and any vendor patches.

  1. Affected versionversion=LRM Versions 1.3 to 3.1

What conditions does exploitation require?

Attack vectornetwork
Required privilegesunauthenticated

What is affected?

Illumina · MiSeqDx Instrumentversion=LRM Versions 1.3 to 3.1
Illumina · MiniSeq Systemversion=LRM Versions 1.3 to 3.1
Illumina · iSeq 100version=LRM Versions 1.3 to 3.1
Illumina · NextSeq 550Dx Instrumentversion=LRM Versions 1.3 to 3.1
Illumina · NextSeq 550 Systemversion=LRM Versions 1.3 to 3.1
Illumina · MiSeq Systemversion=LRM Versions 1.3 to 3.1
Illumina · NextSeq 500 Systemversion=LRM Versions 1.3 to 3.1

Published CVSS scores

9.8NVDCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
10.0ICS-CERTCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:C/C:H/I:H/A:H
7.5NVDAV:N/AC:L/Au:N/C:P/I:P/A:P

CVSS describes severity. EPSS estimates exploitation probability.

Attacks

What attackers are doing with it

Daily unique IPs observed by Shadowserver honeypots for known exploited vulnerabilities (KEVs). Missing observations do not establish an absence of attacks.

Daily unique IPsNo honeypot observations are available for this CVE in the selected window.

No observations available

Sep 9, 2026Sep 15, 2026
Latest reporting daySep 15, 2026
Latest daily unique IPsUnavailable
Prior 30-day averageUnavailable
SourceShadowserver honeypots (KEV)
Vectornetwork
Privilegesunauthenticated
Known exploitationUnconfirmed
Public exploitUnconfirmed

Weakness, pattern, technique

CWE-22Improper Limitation of a Pathname to a Restricted Directory ('Path Traversal')
T1190Exploit Public-Facing Application

Public exploit references

No public exploit references are available in this record.

Labels summarize the accepted research assessment. They do not indicate a test against your environment.

Technologies

Your stack

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Your stack

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