CVE-2022-1517Network attack vector

Unauthenticated code execution via executable web uploads

Published Jun 24, 2022 · Updated Apr 16, 2025

Remote code execution in Illumina Local Run Manager 1.3 through 3.1 allows remote attackers to execute operating-system code via network requests. The IIS-hosted web interface accepts uploaded content and permits the web server to execute it while Local Run Manager runs with elevated privileges. No authentication or user interaction is required, and successful execution grants control over instrument settings, software, sensitive data, and connected-network access.

CVSS severity10.0
Critical
EPSS probability1.78%
Next 30 days · Sep 16, 2026
Known exploitationUnconfirmed
Based on sourced intelligence
Hinoki checkNot available
Coverage for this vulnerability

See if you're affected

Explore vulnerability checks for your environment with Hinoki.

Book a demo

Summary

What happened

Remote code execution in Illumina Local Run Manager 1.3 through 3.1 allows remote attackers to execute operating-system code via network requests. The IIS-hosted web interface accepts uploaded content and permits the web server to execute it while Local Run Manager runs with elevated privileges. No authentication or user interaction is required, and successful execution grants control over instrument settings, software, sensitive data, and connected-network access.

The record

CVE
CVE-2022-1517
Published
Jun 24, 2022
Updated
Apr 16, 2025
Vendor
Illumina
Product
MiSeqDx Instrument
Classifications
CWE-250, CWE-269, T1190
Attack vector
network
Privileges
unauthenticated

Timeline

How it unfolded

  1. Jun 24, 2022CVE publishedPublication date reported by the CVE source.
  2. Apr 16, 2025Record updatedLatest update available in the CVE record.

Exploitability

Present is not the same as exploitable

Compare your product and version with the public record. A matching version still requires validation against your environment.

Is a vulnerable build present?

Compare these published version ranges with your installed build and any vendor patches.

  1. Affected versionversion=LRM Versions 1.3 to 3.1

What conditions does exploitation require?

Attack vectornetwork
Required privilegesunauthenticated

What is affected?

Illumina · MiSeqDx Instrumentversion=LRM Versions 1.3 to 3.1
Illumina · MiniSeq Systemversion=LRM Versions 1.3 to 3.1
Illumina · iSeq 100version=LRM Versions 1.3 to 3.1
Illumina · NextSeq 550Dx Instrumentversion=LRM Versions 1.3 to 3.1
Illumina · NextSeq 550 Systemversion=LRM Versions 1.3 to 3.1
Illumina · MiSeq Systemversion=LRM Versions 1.3 to 3.1
Illumina · NextSeq 500 Systemversion=LRM Versions 1.3 to 3.1

Published CVSS scores

9.8NISTCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
10.0IlluminaCVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:C/C:H/I:H/A:H

CVSS describes severity. EPSS estimates exploitation probability.

Attacks

What attackers are doing with it

Daily unique IPs observed by Shadowserver honeypots for known exploited vulnerabilities (KEVs). Missing observations do not establish an absence of attacks.

Daily unique IPsNo honeypot observations are available for this CVE in the selected window.

No observations available

Sep 9, 2026Sep 15, 2026
Latest reporting daySep 15, 2026
Latest daily unique IPsUnavailable
Prior 30-day averageUnavailable
SourceShadowserver honeypots (KEV)
Vectornetwork
Privilegesunauthenticated
Known exploitationUnconfirmed
Public exploitUnconfirmed

Weakness, pattern, technique

CWE-250Execution with Unnecessary Privileges
CWE-269Improper Privilege Management
T1190Exploit Public-Facing Application

Public exploit references

No public exploit references are available in this record.

Labels summarize the accepted research assessment. They do not indicate a test against your environment.

Technologies

Your stack

See the directory against your own environment.

Your stack

Check the software in your environment

Book a demo to see how Hinoki identifies affected software and validates exploitability in your environment.

Book a demo